Beilstein J. Org. Chem.2022,18, 1454–1456, doi:10.3762/bjoc.18.150
, Colombia 10.3762/bjoc.18.150 In the past ten years, the use of mechanochemical techniques (e.g., grinding, milling, extrusion, pulsedultrasonication, resonant acoustic mixing, etc.) have widespread in the field of organic chemistry, enabling the development of new and more sustainable protocols for
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Graphical Abstract
Scheme 1:
a) Mechanochemical PEG-400-assisted halogenation of phenols and anilines using NXS. b) Halogenation...
Beilstein J. Org. Chem.2022,18, 1225–1235, doi:10.3762/bjoc.18.128
molecule mechanochemistry sometimes overlap, evidencing the connection between both approaches.
Keywords: ball milling; mechanochemistry; mechanophore; polymer; pulsedultrasonication; Introduction
In the past two decades, the growth in popularity of mechanochemistry has been unmistakable. During this
(mechanophores) embedded along the polymer chains (Figure 1a) [1][2][3][4].
This is mostly accomplished through pulsedultrasonication, and to a lesser extent by single-molecule force spectroscopy techniques [5][6]. The second approach habitually makes use of ball milling techniques to bring together small
created two seemingly distinct lines of thought within the field of mechanochemistry, which kept both areas to evolve mostly separately. On the one hand, polymer mechanochemistry by pulsedultrasonication is believed to exhibit higher control at the microscopic level, for example, by enabling the
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Graphical Abstract
Figure 1:
Representation of (a) cavitation and elongational flow caused by pulsed ultrasonication, (b) mixer ...